Bruno Botta is full professor and he has been nominated Deputy Provst for the Internationalization in November 2014. He is Head of the Dipartimento di Chimica e Tecnologie del Farmaco at Sapienza University of Rome since 2011. Since March, 16, 2015 he is Chair of the Cost Action CM-1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery". His interest during the years has been focused on the structural elucidation and synthesis of biologically active compounds derived from living plants. Since 20 years, he has been working on the field of plant tissue cultures in combination with chemistry directed toward the understanding of biosynthetic pathways of the compounds under investigation. During the years, some plant enzymes (such as those belonging to the peroxidases family) derived from the above-mentioned cell cultures have been isolated and purified and some kinetic studies have been performed too. During the last 15 years, Prof. Botta focused his attention also on both the synthesis and host-guest studies of artificial receptors of the resorcarenes family.
During the last 7 years he focused his attention on the Hedgehog (Hh) signalling pathway which plays a pivotal role in the initiation, proliferation, invasion and metastasis of various cancers (inter alia medulloblastoma).
He is author of 140 publications, including 6 patents (3 national and 3 international – USA and Europe), and, besides that, he is author and co-author of 10 books. For the Italian publishing house Edi-Ermes he edited 2 text books of Organic Chemistry.