Selected Publications (2004-2016)

 

Publications

  1. Aiello, F., Balzano, F., Ghirga, F., D’Acquarica, I., Botta, B., Uccello-Barretta, G., Quaglio D. First detection of a ruthenium-carbene resorc[4]arene complex during the progress of a metathesis reaction. EUR Journal of Organic Chemistry 2016, published online.
  2. Iovine, V., Benni, I., Sabia, R., D’Acquarica, I., Fabrizi, G., Botta, B., Calcaterra, C. Total Synthesis of (±)-Kuwanol E. Journal of Natural Product 2016, 79 (10), pp. 2495-2503.
  3. Cevatemre, B.Botta, B.Mori, M.Berardozzi, S.Ingallina, C.Ulukaya, E. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Chemico-Biological Interactions 2016, 260, pp.  248-255.
  4. Dear Evain-Bana, E., Schiavo, L., Bour, C., Lanfranchi, D-A, Berardozzi, S., Ghirga, F., Bagrel, D., Botta, B., Hanquet, G., Mori, M. Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases. Journal of enzyme inhibition and medicinal chemistry 2016, published online.
  5. Infante, P., Alfonsi, R., Ingallina, C., Quaglio, D., Ghirga, F., D’Acquarica, I., Di Magno, L., Canettieri, G., Screpanti, I., Gulino, A., Botta, B., Mori, M., Di Marcotullio, L. Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype. Cell Death & Disease 2016, 7, e2376.
  6. Ingallina, C., Rinaldi, F., Bogni, A., Ponti, J., Passeri, D., Reggente, M., Rossi, M., Kinsner-Ovaskainen, A.; Mehn, D., Rossi, F., Botta, B., Carafa, M., Marianecci, C. Niosomal approach to brain delivery: Development, characterization and in vitro toxicological studies. International journal of pharmaceutics 2016, 511 (2), pp. 969-982.
  7. Barretta, G. U., Balzano, F., Aiello, F., Nardelli, F., Ciogli, A., Calcaterra, A., Botta, B. Covalently assembled resorcin[4]arenes and molecular tweezers: a chiral recognition rationale by NMR. Supramolecular chemistry 2016, 21 (7-8), pp. 647-655.
  8. Ghirga, F., Quaglio, D., Ghirga, P., Berardozzi, S., Zappia, G., Botta, B., Mori, M., D'Acquarica, I. Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine. Chirality 2016, 28 (3), pp. 169-180.
  9. Comba, A., Ainnada, L. L., Tolosa, E. J., Iguchi, E., Marks, D. L., Messler, M. V., Silva, R., Fernandez-Barrena, M. G., Enriquez-Hesles, E., Vrabel, A. L., Botta, B., Di Marcotulio, L., Ellenrieder, V., Eynard, A. R., Pasqualini, M. E., Fernandez-Zapico, M. E. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. Journal of biological chemistry 2016, 291 (4), pp. 1933-1947.
  10. Cirigliano, A., Stirpe, A., Menta, S., Mori, M., Dell'Edera, D., Pick, E., Negri, R., Botta, B., Rinaldi, T. Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5. Journal of enzyme inhibition and medicinal chemistry 2016, 31 (6), pp. 1632-1637.
  11. Navakauskiene, R., Mori, M., Christodoulou, M. S., Zentelyte, A., Botta, B., Dalla Via, L., Ricci, F., Damia, G., Passarella, D., Zilio, C., Martinet, N. Histone demethylating agents as potential S-adenosyl-L-methionine-competitors. Medicinal Chemical Communications 2016, 7 (6), pp. 1245-1255.
  12. Mascarello, A., Chiaradia-Delatorre, L. D., Mori, M., Terenzi, H., Botta, B. Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs. Current pharmaceutical design 2016, 22 (12), pp. 1561-1569.
  13. D’Acquarica, I., Ghirga, F., Ingallina, C., Quaglio, D., Zappia, G., Uccello-Barretta, G., Balzano, F., Botta, B. Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry. In book: Calixarenes and Beyond 2016, pp. 175-193.
  14. Iovine, V., Mori, M., Calcaterra, A., Berardozzi, S., Botta, B. One Hundred Faces of Cyclopamine. Current pharmaceutical design 2016, 22 (12), pp. 1658-1681.
  15. D'Acquarica, I., Ghirga, F., Quaglio, D., Cerreto, A., Ingallina, C., Tafi, A., Botta, B. Molecular Recognition of Natural Products by Resorc[4]arene Receptors. Current pharmaceutical design (2016), 22 (12), pp. 1715-1729.
  16. Khan, M. I., Sobocinska, A. A., Czarnecka, A. M., Krol, M., Botta, B., Szczylik, C. The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory. Current pharmaceutical design 2016, 22 (12), pp. 1756-1766.
  17. Ingallina, C., D’Acquarica, I.,  Monache, G.D.,  Ghirga, F.,  Quaglio, D.,  Ghirga, P.,  Berardozzi, S.,  Markovic, V.,  Botta, B., The pictet-spengler reaction still on stage. Current Pharmaceutical Design 2016, 22 (12), pp. 1808-1850.
  18. Esposito, F., Tintori, C., Martini, R., Christ, F., Debyser, Z., Ferrarese, R., Cabiddu, G., Corona, A., Ceresola, E. R., Calcaterra, A., Iovine, V., Botta, B., Clementi, M., Canducci, F., Botta, M., Tramontano, E. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. ChemBioChem 2015, 16 (17), pp. 2507-2512.
  19. Martins, P. G. A., Mori, M., Chiaradia-Delatorre, L. D., Menegatti, A. C. O., Mascarello, A., Botta, B., Benitez, J., Gambino, D., Terenzi, H. Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies. ACS Medicinal Chemistry Letters 2015, 6 (10), pp. 1035-1040.
  20. Christodoulou, M. S., Mori, M., Pantano, R., Alfonsi, R., Infante, P., Botta, M., Damia, G., Ricci, F., Sotiropoulou, P. A., Liekens, S., Botta, B., Passarella, D.. Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib. ChemPlusChem 2015, 80(6), pp. 938-943.
  21. Infante, P., Alfonsi, R., Botta, B., Mori, M., Di Marcotullio, L. Targeting Gli factors to inhibit the Hedgehog pathway. Trends in Pharmacological Sciences 2015, 36(8), pp. 547-558.
  22. Infante, P., Mori, M., Alfonsi, R., Ghirga, F., Aiello, F., Toscano S., Ingallina C., Siler M., Cucchi D., Po A., Miele E., D’Amico D., Canettieri, G., De Smaele, E., Ferretti, E., Screpanti, I., Uccello Barretta, G., Botta, M., Botta, B., Gulino, A., and Di Marcotullio, L.. Gli1/DNA interaction is a druggable target for Hedgehogdependent tumors. EMBO Journal 2015 34(2), pp. 200-217.
  23. Uccello-Barretta, G., Balzano, F., Aiello, F., Vanni, L., Mori, M., Menta, S., Calcaterra, A., Botta, B.. Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(d-leucyl-d-valinamido) resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach. Organic & Biomolecular Chemistry 2015, 13(3), pp. 916-924.
  24. Ghirga, F., Quaglio, D., Iovine, V., Botta, B., Pierini, M., Mannina, L., Sobolev, A. P., Ugozzoli, F., D' Acquarica, I. Synthesis of a Double-Spanned-Resorc[4]arene via Ring-Closing Metathesis and Calculation of Aggregation Propensity. Journal of Organic Chemistry 2014, 79 (22), pp. 11051-11060.
  25. D'Acquarica, I., Calcaterra, A., Sacco, F., Balzano, F., Aiello, F., Tafi, A., Pesci, N., Uccello-Barretta, G., Botta, B. Stereochemical preference of 2'-deoxycytidine for chiral bis(diamido)-bridged basket resorcin[4]arenes. Chirality 2013, 25 (12), pp. 840-851.
  26. Cerreto, A., Corrente, F., Botta, B., Pacelli, S., Paolicelli, P., Mannina, L., Casadei, M.A. NMR Characterization of Carboxymethyl Scleroglucan. International Journal of Polymer Analysis and Characterization 2013, 18 (8), pp. 587-595.
  27. Ghirga, F., D'Acquarica, I., Delle Monache, G., Toscano, S., Mannina, L., Sobolev, A.P., Ugozzoli, F., Crocco, D., Antiochia, R., Botta, B. Undecenyl resorc[4]arene in the chair conformation as preorganized synthon for olefin metathesis. RSC Advances 2013, 3 (38), pp. 17567-17576.
  28. Mascarello, A., Mori, M., Chiaradia-Delatorre, L.D., Menegatti, A.C.O., de Monache, F., Ferrari, F., Yunes, R.A., Nunes, R.J., Terenzi, H., Botta, B., Botta, M. Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products. PLoS ONE 2013, 8 (10), art. no. e77081.
  29. Rondino, F., Ciavardini, A., Satta, M., Paladini, A., Fraschetti, C., Filippi, A., Botta, B., Calcaterra, A., Speranza, M., Giardini, A., Piccirillo, S. Ultraviolet and infrared spectroscopy of neutral and ionic non-covalent diastereomeric complexes in the gas phase. Rendiconti Lincei 2013, 24 (3), pp. 259-267.
  30. Ghirga, F., D'Acquarica, I., Delle Monache, G., Mannina, L., Molinaro, C., Nevola, L., Sobolev, A.P., Pierini, M., Botta, B. Reaction of nitrosonium cation with resorc[4]arenes activated by supramolecular control: Covalent bond formation. Journal of Organic Chemistry 2013, 78 (14), pp. 6935-6946.
  31. Friggeri, L., Scipione, L., Costi, R., Kaiser, M., Moraca, F., Zamperini, C., Botta, B., Di Santo, R., De Vita, D., Brun, R., Tortorella, S. New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS Medicinal Chemistry Letters 2013, 4 (6), pp. 538-541.
  32. Filippi, A., Fraschetti, C., Piccirillo, S., Rondino, F., Botta, B., D'Acquarica, I., Calcaterra, A., Speranza, M. Chirality effects on the IRMPD spectra of basket resorcinarene/nucleoside complexes. Chemistry - A European Journal 2012, 18 (27), pp. 8320-8328.
  33. Menendez, P., D'Acquarica, I., Delle Monache, G., Ghirga, F., Calcaterra, A., Barba, M., Macone, A., Boffi, A., Bonamore, A., Botta, B. Production of Bioactives Compounds: The Importance of Pictet-Spengler Reaction in the XXI Century. Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives 2012, pp. 453-487.
  34. D’Acquarica, I., Cerreto, A., Delle Monache, G., Subrizi, F., Boffi, A., Tafi, A., Forli, S., Botta, B. N-linked peptidoresorc[4]arene-based receptors as noncompetitive inhibitors for α-chymotrypsin. Journal of Organic Chemistry 2011, 76 (11), pp. 4396-4407.
  35. Macone, A., Fontana, M., Barba, M., Botta, B., Nardini, M., Ghirga, F., Calcaterra, A., Pecci, L., Matarese, R.M. Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: A review. International Journal of Molecular Sciences 2011, 12 (5), pp. 3072-3084.
  36. Botta, B., Fraschetti, C., D'Acquarica, I., Sacco, F., Mattay, J., Letzel, M.C., Speranza, M. Unprecedented gas-phase chiroselective logic gates. Organic and Biomolecular Chemistry 2011, 9 (6), pp. 1717-1719.
  37. Bonamore, A., Rovardi, I., Gasparrini, F., Baiocco, P., Barba, M., Molinaro, C., Botta, B., Boffi, A., MacOne, A. An enzymatic, stereoselective synthesis of (S)-norcoclaurine. Green Chemistry 2010, 12 (9), pp. 1623-1627.
  38. Basile, A., Botta, B., Bruno, M., Rigano, D., Sorbo, S., Conte, B., Rosselli, S., Senatore, F. Effects of air pollution on production of essential oil in Feijoa Sellowiana Berg. grown in the 'Italian triangle of death' International Journal of Environment and Health. 2010, 4 (2-3), pp. 250-259.
  39. Bonamore, A., Barba, M., Botta, B., Boffi, A., Macone, A. Norcoclaurine synthase: Mechanism of an enantioselective Pictet-Spengler catalyzing enzyme. Molecules 2010, 15 (4), pp. 2070-2078.
  40. Speranza, M., D'Acquarica, I., Fraschetti, C., Botta, B., Tafi, A., Bellucci, L., Zappia, G. Diastereoselective gas-phase ion/molecule reactions of ethanolamine neurotransmitter/amido[4]resorcinarene adducts. International Journal of Mass Spectrometry 2010, 291 (1-2), pp. 84-89.
  41. Botta, B., Fraschetti, C., D'Acquarica, I., Speranza, M., Novara, F.R., Mattay, J., Letzel, M.C. Gas-Phase enantioselectivity of chiral N-Linked peptidoresorc[4]arene isomers toward dipeptides. Journal of Physical Chemistry A 2009, 113 (52), pp. 14625-14629.
  42. Torge, R., Comandini, A., Catacchio, B., Bonamore, A., Botta, B., Boffi, A.  Peroxidase-like activity of Thermobifida fusca hemoglobin: The oxidation of dibenzylbutanolide. Journal of Molecular Catalysis B: Enzymatic 2009, 61 (3-4), pp. 303-308.
  43. Botta, B., Menendez, P., Zappia, G., De Lima, R.A., Torge, R., Delle Monache, G. Prenylated isoflavonoids: Botanical distribution, structures, biological activities and biotechnological studies. An update (1995-2006) Current Medicinal Chemistry 2009, 16 (26), pp. 3414-3468.
  44. Zappia, G., Menendez, M.P., De Andrade Lima, C.S., Botta, B. A p-quinol isoflavan and two new isoflavanones from Desmodium canum. Natural Product Research 2009, 23 (7), pp. 665-671.
  45. Botta, B., Fraschetti, C., Novara, F.R., Tafi, A., Sacco, F., Mannina, L., Sobolev, A.P., Mattay, J., Letzel, M.C., Speranza, M. Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: A dynamic, kinetic, and spectroscopic study. Organic and Biomolecular Chemistry 2009, 7 (9), pp. 1798-1806.
  46. Speranza, M., Gasparrini, F., Botta, B., Villani, C., Subissati, D., Fraschetti, C., Subrizi, F.  Gas-phase enantioselective reactions in noncovalent ion-molecule complexes. Chirality 2009, 21 (1), pp. 69-86.
  47. Ilari, A., Franceschini, S., Bonamore, A., Arenghi, F., Botta, B., Macone, A., Pasquo, A., Bellucci, L., Boffi, A. Structural basis of enzymatic (S)-norcoclaurine biosynthesis. Journal of Biological Chemistry 2009, 284 (2), pp. 897-904.
  48. Botta, B., Pierini, M., Delle Monache, G., Subissati, D., Subrizi, F., Zappia, G. Synthesis of amino and ammonium resorcin[4]arenes as potential receptors. Synthesis 2008, (13), pp. 2110-2116.
  49. Botta, B., Tafi, A., Caporuscio, F., Botta, M., Nevola, L., D'Acquarica, I., Frascherti, C., Speranza, M. Modelling amphetamine/receptor interactions: A gas-phase study of complexes formed between amphetamine and some chiral amido[4] resorcinarenes. Chemistry - A European Journal 2008, 14 (12), pp. 3585-3595.
  50. Poce, G., Zappia, G., Porretta, G.C., Botta, B., Biava, M. New oxazolidinone derivatives as antibacterial agents with improved activity. Expert Opinion on Therapeutic Patents 2008, 18 (2), pp. 97-121.
  51. Botta, B., D'Acquarica, I., Nevola, L., Sacco, F., Valbuena Lopez, Z., Zappia, G., Fraschetti, C., Speranza, M., Tafi, A., Caporuscio, F., Letzel, M.C., Mattay, J. Bis(diamido)-bridged basket resorcin[4]arenes as enantioselective receptors for amino acids and amines. European Journal of Organic Chemistry 2007, (36), pp. 5995-6002.
  52. Zappia, G., Gacs-Baitz, E., Delle Monache, G., Misiti, D., Nevola, L., Botta, B. Oxazolidin-2-one ring, a popular framework in synthetic organic chemistry: Part 1. The construction of the oxazolidin-2-one ring. Current Organic Synthesis 2007, 4 (1), pp. 81-135.
  53. Zappia, G., Cancelliere, G., Gacs-Baitz, E., Delle Monache, G., Misiti, D., Nevola, L., Botta, B. Oxazolidin-2-one ring, a popular framework in synthetic organic chemistry: Part 2. Applications and modifications. Current Organic Synthesis 2007, 4 (3), pp. 238-307.
  54. Botta, B., D'Acquarica, I., Delle Monache, G., Subissati, D., Uccello-Barretta, G., Mastrini, M., Nazzi, S., Speranza, M. Synthesis and host-guest studies of chiral N-linked peptidoresorc[4]arenes. Journal of Organic Chemistry 2007, 72 (24), pp. 9283-9290.
  55. Botta, B., Delle Monache, G., Fraschetti, C., Nevola, L., Subissati, D., Speranza, M. Gaseous- versus solution-phase recognition of some aromatic amino esters by 2,8,14,20-tetrakis(L-valinamido)[4]resorcinarene. International Journal of Mass Spectrometry 2007, 267 (1-3), pp. 24-29.
  56. Botta, B., D'Acquarica, I., Delle Monache, G., Nevola, L., Tullo, D., Ugozzoli, F., Pierini, M. Nitrosonium complexes of resorc[4]arenes: Spectral, kinetic, and theoretical studies. Journal of the American Chemical Society 2007, 129 (36), pp. 11202-11212.
  57. Zappia, G., Menendez, P., Delle Monache, G., Misiti, D., Nevola, L., Botta, B. The contribution of oxazolidinone frame to the biological activity of pharmaceutical drugs and natural products. Mini-Reviews in Medicinal Chemistry 2007, 7 (4), pp. 389-409.
  58. Lima, C.S.D.A., Zappia, G., Delle Monache, G., Botta, B. Uncommon 5-methoxyisoflavans from Desmodium canum. European Journal of Organic Chemistry 2006, (24), pp. 5445-5448.
  59. Botta, B., Caporuscio, F., D'Acquarica, I., Delle Monache, G., Subissati, D., Tafi, A., Botta, M., Filippi, A., Speranza, M. Gas-phase enantioselectivity of chiral amido[4]resorcinarene receptors. Chemistry - A European Journal 2006, 12 (31), pp. 8096-8105.
  60. Vitali, A., Pacini, L., Bordi, E., De Mori, P., Pucillo, L., Maras, B., Botta, B., Brancaccio, A., Giardina, B. Purification and characterization of an antifungal thaumatin-like protein from Cassia didymobotrya cell culture. Plant Physiology and Biochemistry 2006, 44 (10), pp. 604-610.
  61. D'Acquarica, I., Nevola, L., Delle Monache, G., Gács-Baitz, E., Massera, C., Ugozzoli, F., Zappia, G., Botta, B. Cyanoresorc[5]arenes: Isolation, conformation and crystal structure. European Journal of Organic Chemistry 2006, (16), pp. 3652-3660.
  62. Botta, B., Caporuscio, F., Subissati, D., Tafi, A., Botta, M., Filippi, A., Speranza, M. Flattened cone 2,8,14,20-tetrakis(L-valinamido)-[4]resorcinarene: An enantioselective allosteric receptor in the gas phase Angewandte Chemie - International Edition 2006, 45 (17), pp. 2717-2720.
  63. Pasqua, G., Silvestrini, A., Monacelli, B., Mulinacci, N., Menendez, P., Botta, B. Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne. Plant Physiology and Biochemistry 2006, 44 (4), pp. 220-225.
  64. Botta, B., Delle Monache, G., Menendez, P., Boffi, A. Novel prenyltransferase enzymes as a tool for flavonoid prenylation. Trends in Pharmacological Sciences 2005, 26 (12), pp. 606-608.
  65. Botta, B., Cassani, M., D'Acquarica, I., Subissati, D., Zappia, G., Delle Monache, G. Resorcarenes: Hollow building blocks for the host-guest chemistry. Current Organic Chemistry 2005, 9 (12), pp. 1167-1202.
  66. Botta, B., Vitali, A., Menendez, P., Misiti, D., Delle Monache, G. Prenylated flavonoids: Pharmacology and biotechnology. Current Medicinal Chemistry 2005, 12 (6), pp. 713-739.
  67. Botta, B., Cassani, M., D'Acquarica, I., Misiti, D., Subissati, D., Delle Monache, G. Resorcarenes: Emerging class of macrocyclic receptors. Current Organic Chemistry 2005, 9 (4), pp. 337-355.
  68. Ferrari, F., Pasqua, G., Monacelli, B., Cimino, P., Botta, B. Xanthones from calli of Hypericum perforatum subsp. Perforatum. Natural Product Research 2005, 19 (2), pp. 171-176.
  69. Tafi, A., Botta, B., Botta, M., Delle Monache, G., Filippi, A., Speranza, M. Chiral recognition by resorcin[4]arene receptors: Intrinsic kinetics and dynamics. Chemistry - A European Journal 2004, 10 (17), pp. 4126-4135.
  70. Botta, B., Subissati, D., Tafi, A., Delle Monache, G., Filippi, A., Speranza, M. Cavity effects on the enantioselectivity of chiral amido[4]resorcinarene stereoisomers. Angewandte Chemie - International Edition 2004, 43 (36), pp. 4767-4770.
  71. Vitali, A., Giardina, B., Delle Monache, G., Rocca, F., Silvestrini, A., Tafi, A., Botta, B. Chalcone dimethylallyltransferase from Morus nigra cell cultures. Substrate specificity studies FEBS. Letters 2004, 557 (1-3), pp. 33-38.

Patents

  1. B. Botta; A. Gulino; M. Botta; M. Mori; L. Di Marcotullio; P. Infante; F. Ghirga; S. Toscano; C. Ingallina; R. Alfonsi (2014). Multitarget hedgehog pathway inhibitors and uses thereof, PCT EP 2014063449.
  2. B. Botta; A. Gulino; M. Botta; M. Mori; L. Di Marcotullio; P. Infante; F. Ghirga; S. Toscano; C. Ingallina; R. Alfonsi (2013). Multitarget hedgehog pathway inhibitors and uses thereof, RM2013A000366
  3. A. Nunziata, G. Lionetti, E. Pierri, B. Botta, G. Cancelliere, I. D’acquarica, G. Delle Monache, F. Gasparrini, L. Nevola, D. Subissati, C. Villani (2007). Method of reducing the level of nitrogen oxides in a medium by absorption with resorcin[4]arenes. EP1738821, British American Tobacco Italia S.P.A.
  4. A. Nunziata, G. Lionetti, E. Pierri, B. Botta, G. Cancelliere, I. D’acquarica, G. Delle Monache, F. Gasparrini, L. Nevola, D. Subissati, C. Villani, M. Cassani (2006). Synthesis of resorcin[4]arenes and their use to adsorb nitrogen oxides from tobacco smoke. WO2006136950, British American Tobacco-Italia s.r.l.
  5. G. Delle Monache; F. Delle Monache; M. Carmignani; S. C. Bonnevaux; R. Espinal; C. De Luca; B. Botta (1991). Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them, PCT US 5059624 A
  6. G. Delle Monache; F. Delle Monache; B. Botta; S. C. Bonnevaux; R. Espinal; C. De Luca; M. Carmignani (1989). Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them, EP 330629 A2 19890830.

Selected Books

Menendez, P.; D'Acquarica, I.; Delle Monache, G.; Ghirga, F.; Calcaterra, A.; Barba, M.; Macone, A.; Boffi, A.; Bonamore, A.; Botta, B.  Production of bioactives compounds: The importance of Pictet-Spengler reaction in the XXI century. In   Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives. John Wiley & Sons, Inc., Hoboken, NJ-USA, 2012.

Botta, Bruno editor Chimica Organica Essenziale, 2012 Edi.Ermes s.r.l. Milano.

Botta, Bruno editor Chimica Organica 2011 Edi.Ermes s.r.l. Milano.